An Ode to Cytochrome C Mediated Apoptosis
Cytochrome C, what came of thee?
I think I see where you went wrong,
to which I respond with this song.
Now Bax and Bak, dirty devils,
got together and made some channels.
Alone they could do no such thing
so Bid and Bim got in the swing.
Now Bid and Bim spell certain doom
(when Bim's not leading bands with brooms*).
But, hold, there is a saviour yet,
a protein that acts like a net!
Now, Bcl don't rhyme so well
except with quell, and fell and dwell.
All things are named, that is true,
and so we have xL and 2.
xL and 2 they can sequester
Bid and Bim before disaster.
And what's more, I'm glad to say,
They can keep Bax and Bak at bay.
Oh no, now, how could it be so
that something else jumped in the row!
Bad and Bik cut through these ties
and quickly they do sensitize
those devils, Bid and Bim, which fling
from Bcl, and then they cling
to Bax and Bak, which are now free
to open pores for cyto c!
Then, my friend, it's off to the races
because we now have the caspaces.
Now none can save, and I anoint
this cell beyond commitment point.
Now, that is all, this cell's life's dim
Because of Bax, Bad, Bik and Bim.